• verb:   reduce in population
• verb:   leave someone who needs or counts on you; leave in the lurch
• verb:   devastate or ravage
• adjective:   crushed by grief

  Example: "Depressed and desolate of soul"

• adjective:   pitiable in circumstances especially through abandonment

  Example: "Desolate and despairing"

• adjective:   made uninhabitable
• adjective:   providing no shelter or sustenance

  Example: "The desolate surface of the moon"

Related words...