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Definitions of triple whammy:
  • noun:   (informal) A threefold blow or setback.
  • noun:   (medicine, informal) An angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, combined with a diuretic and a non-steroidal anti-inflammatory drug, the concurrent use of which may precipitate acute kidney injury.

(Definitions from Wiktionary)

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